Medical Studies Database

cannabidiol · cannabis · CBD · Nervous System · Sleep ·Jul 06, 2021

Cannabinoids, Endocannabinoids and Sleep

Abstract: Sleep is a vital function of the nervous system that contributes to brain and bodily homeostasis, energy levels, cognitive ability, and other key functions of a variety of organisms. Dysfunctional sleep induces neural problems and is a key part...

Anxiety · cannabidiol · cannabis · CBD · Depression ·Jul 06, 2021

Effects of cannabidiol in males and females in two different rat models of depression

Abstract: The current study explores the therapeutic potential of Cannabidiol (CBD), a compound in the Cannabis plant, using both sexes of 2 “depressive-like” genetic models, Wistar Kyoto (WKY) and Flinders Sensitive Line (FSL) rats. Rats ingested CBD (30 mg/kg) orally. In the saccharin preference test,...

Anxiety · cannabidiol · cannabis · CBD · Depression · Endocannabinoid System · Endocannabinoids · Nervous System ·Jul 06, 2021

Emerging evidence for the antidepressant effect of cannabidiol and the underlying molecular mechanisms

Abstract: Significant limitations with the currently available antidepressant treatment strategies have inspired research on finding new and more efficient drugs to treat depression. Cannabidiol (CBD) is a non-psychotomimetic component of Cannabis sativa, and emerges in this regard as a promising...

Anxiety · cannabidiol · CBD · Depression · Endocannabinoid System · Endocannabinoids ·Jul 06, 2021

Antidepressant-like effects of cannabidiol in mice: possible involvement of 5-HT1A receptors

Abstract: Background and purpose: Cannabidiol (CBD) is a non-psychotomimetic compound from Cannabis sativa that induces anxiolytic- and antipsychotic-like effects in animal models. Effects of CBD may be mediated by the activation of 5-HT(1A) receptors. As 5-HT(1A) receptor activation may induce antidepressant-like...

Anxiety · cannabidiol · cannabis · CBD · Depression ·Jul 06, 2021

Cannabidiol Induces Rapid and Sustained Antidepressant-Like Effects Through Increased BDNF Signaling and Synaptogenesis in the Prefrontal Cortex

Abstract: Currently available antidepressants have a substantial time lag to induce therapeutic response and a relatively low efficacy. The development of drugs that addresses these limitations is critical to improving public health. Cannabidiol (CBD), a non-psychotomimetic component of Cannabis sativa,...